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Abstract #5150

Impact of radiographer-led change on cMRI protocol in porcine stem cell study

Naeim Nick Sanaei1, Anthea Lok Lon Min1, Dinesh Selvakumar1, Tejas Deshmukh1, Arthur Escalona1, Dennis Wong1, Vien Mouangvong1, Brendan Evans2, Pathan Faraz3, James Chong1, and Sheryl Foster1
1Westmead Hospital, Sydney, Australia, 2Sectra, Sydney, Australia, 3Sydney University, Sydney, Australia

Synopsis

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Motivation: Knowledge that a suboptimal acquisition protocol was being implemented in a large and expensive animal research study.

Goal(s): Demonstration of improved image quality in a porcine study investigating remuscularisation effects of stem cell treatment in diseased and injured hearts.

Approach: Implementation of a FB protocol in tandem with a BH protocol in a subset of porcine subjects (n=38) who had undergone percutaneous induction of myocardial infarction.

Results: Superior image quality and greater reproducibility of BH techniques with shorter scan times results in the need for remarkably smaller sample sizes to show clinically significant treatment effects.

Impact: MRI radiographers are an untapped resource in many sites performing research. This study demonstrated the impact of radiographer expertise in protocol development and subsequent improvement in research data quality and outcomes in a large and expensive animal study.

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