Motivation: Real-time imaging protocol based on hyperpolarized 13C pyruvate to probe metabolic changes in patients undergoing standard-of-care chemotherapy for breast cancer, with cardiotoxic potential.
Goal(s): An imaging protocol that results in high-quality reproducible B0 heart shimming. To implement an echo-shifted mDIXON acquisition with spatial-spectral excitation to detect pyruvate and its major byproducts. A processing pipeline for reconstruction of metabolic images.
Approach: Single-shot EPI acquisitions with shifted echo times (n=6) were acquired following a SpSp excitation, as to generate signal for mDIXON / IDEAL reconstructed images of these metabolites.
Results: We have established a real-time 13C-hyperpolarization and imaging protocol and reconstruction pipeline
Impact: Noninvasive real-time metabolic imaging using hyperpolarized 13C may aid clinical evaluation of possible cardiac toxicity for breast cancer patients
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