Motivation: Neuromelanin and nigrosome1 imaging are each instrumental in diagnosing Parkinson's disease but have been utilized separately due to constraints like extended scan time.
Goal(s): To propose a 3D multi-echo GRE sequence for simultaneous imaging of neuromelanin and nigrosome1 that can be executed in a clinical setting (~5min).
Approach: The previously suggested protocols for neuromelanin and nigrosome1 imaging were modified. DL-based analyses are employed for the automated detection and segmentation of neuromelanin, and for identifying the nigrosome1 regions.
Results: The proposed method yields reliable estimates of neuromelanin-related volumes and identifies the nigrosome1 regions within a clinically acceptable scan time.
Impact: A simultaneous neuromelanin and nigrosome1 imaging protocol was implemented within a practically feasible scan time. It achieved robust visualization of the loss of the swallow tail sign and demonstrated strong sensitivity to changes in the neuromelanin signal.
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