Motivation: There is a lack of effective MR tool for early diagnosis of AD.
Goal(s): To assess the value of CEST MRI for early detection of AD using a transgenic rat model.
Approach: CEST MRI scans for 10 AD rats and 9 age-matched wide-type (WT) controls were performed on 9.4T animal MR scanner. CEST signals were quantified using Lorentzian Difference, with signals at multiple frequency offsets quantified.
Results: Compared with WT rats, pCr and G-amine signals in several brain regions of AD rats were significantly decreased, which is expected to be used as biomarkers for early detection of AD.
Impact: The study provides evidence for early detection of AD in transgenic rat brains using in vivo CEST MRI and may promote clinical translation.
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