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Abstract #7991

BOLD Signal/Physiology

Molly G Bright1,2

1Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Division of Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Functional MRI has become a standard technique for exploring brain function, however this imaging modality is not a direct measure of neural activity. This course introduces the source of Blood Oxygenation Level Dependent (BOLD) contrast and the physiological mechanisms that drive the haemodynamic response to neural activity. The limitations and challenges of using blood as a surrogate for brain function are discussed, particularly in cohorts with differing cerebrovascular physiology. Potential solutions involving additional imaging modalities and complementary MRI contrast mechanisms may enable accurate understanding of the neuro-vascular processes underlying BOLD fMRI.

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