This talk covers the applications of multi-echo (ME)-fMRI in combination with independent components analysis (ICA), called ME-ICA (Kundu et al., 2011). The ME-ICA approach to fMRI acquisition and analysis greatly increases the fidelity of BOLD fMRI while reducing the burden of artifacts across fMRI applications. Thus, the target audience of this talk includes all users of fMRI. Examples include users of resting state fMRI, task-based fMRI, pharmaco-fMRI, clinical fMRI of patients with lesions, and preclinical fMRI. The evidence presented indicates that the ME-fMRI approach expands the range of experiments that is practicable using fMRI.