Amide proton transfer-weighted (APTw) imaging, a variant of the CEST-based molecular MRI technique, is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of mobile proteins and peptides. Theoretically, the APTw-MRI signal relies mainly on the mobile amide proton concentration and amide proton exchange rate which are related to tissue pH. Therefore, APTw-MRI has the potential to detect brain tumors (where many proteins are overexpressed) and ischemic strokes (where pH drop). Early pre-clinical and clinical data suggest that APTw imaging has unique features by which to detect and characterize brain tumors and strokes.
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