The goal of this presentation is to critically present the potential and limitations of hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging (HP 13C MRSI) for diagnosis and monitoring of non-cancer neurological disorders. We will present in vivo studies in which hyperpolarized [1-13C] pyruvate was used to monitor neuroinflammation in preclinical models of Multiple Sclerosis and Traumatic Brain Injury, and discuss the results. We will also give an overview on how to design hyperpolarized 13C probes for metabolic imaging, and discuss the technical and biological requirements of such imaging agents with a special focus on brain.
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