This lecture will describe the gadolinium based MRI contrast agents (GBCA) used in musculoskeletal MRI imaging. It will describe basic design and function principles and historical development of the GBCA emphasizing the links between chemical structure and gadolinium dissociation and deposition. Emphasis will also be placed on appreciation of the hierarchy of data from in vivo human to physical chemical numbers like binding constants and kinetics of dissociation. Recent findings and toxicologic studies will be described, as well as a look to the future of the field.
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