MRI Monitoring of Neoadjuvant Chemotherapy Response in Breast Cancer of Different Phenotypes to Doxorubicin-Cyclophosphamide followed by Taxane + Carboplatin Trastuzumab Regimen
Mehta R, Chen J, Hsiang D, Su M, Yu H, Carpenter P, Nalcioglu O, Schubbert T
University of California
The response of breast cancer to AC, and AC followed by Carboplatin-Taxel Herceptin was studied in 53 patients. The lesions were classified into 4 types: mass, multi-nodule, diffuse, and septal pattern. With the more aggressive Taxane protocol, 25/36 achieved a complete response on MRI, with 18/21 cases proven to have a pathological complete response. The responses to three treatment regimens were significantly different, CR was found in 0/13 in AC groups, 13/23 in Her2/neu negative patients receiving AC+TCa, and 12/12 in Her2/neu positive patients receiving AC+TCaH. The MRI phenotype was not associated with response, thus not a good predictor.