Predicting the Response of Neo-adjuvant Chemotherapy in Locally Advanced Breast Cancer Patients by Diffusion Weighted Imaging
Jagannathan N, Danishad K, Seenu V
All India Institute of Medical Sciences
Diffusion weighted MR imaging was carried out in breast cancer patients prior to neo-adjuvant chemotherapy and after chemotherapy along with twelve normal subjects. The ADC value obtained in tumors was significantly lower compared to the normal breast indicating high cellularity and restricted water diffusion. Significant increase in ADC from pre-therapy value was observed after therapy in responders while non responders showed only a marginal increase. Chemotherapy induced reduction in tumor volume was correlated with the change in ADC. The study proved the significance of DW-MRI in the evaluation of the response of the tumor to therapy in a clinical setting.