Effect of Transcytolemmal Water Exchange in DCE-MRI Data Analysis of Human Head and Neck Cancer
Quon H, Kim S, Loevner L, Rosen M, Glickson J, Kilger A, Poptani H
University of Pennsylvania
The dynamics of contrast reagent uptake has often been analyzed using the Kety-Schmidt two-compartment model assuming the trancytolemmal water exchange rate does not affect the DCE-MRI data. Recently, it has been demonstrated in animal tumor models that deviations from this assumption need to be taken into account. In the present study, we compared the goodness of fitting for Kety-Schmidt model with or without taking into account the trancytolemmal water exchange rate and conclude that the effect of water exchange needs to be considered in the quantitative analysis of contrast reagent uptake in human head and neck cancer.