Test-retest Reliability of Dorsolateral Prefrontal Cortical GABA Measurement using an 8-Channel Phased-Array Head Coil with the J-editing Technique at 3T
Gonzales R, Soones T, Shungu D, Dyke J, Mao X, Kegeles L
Measurement of brain GABA and glutamate/glutamine in the dorsolateral prefrontal cortex (DLPFC) is of central interest in many neuropsychiatric disorders. Previous work has shown the feasibility of reliable measurements at 3T with MRS and the J editing technique using a single-channel quadrature volume head coil, with fairly large (19.5 cc) voxel of interest (VOI). Significant SNR gains have been found to be attainable in this region with a multichannel phased-array coil. This study shows the feasibility of utilizing the SNR gains of a multichannel phased-array coil to reduce the DLPFC VOI volume to 9 cc without degradation of test-retest reliability.