Residual water as a navigator in GABA editing spectroscopy
Shen J, van der Veen J
GABA is the primary inhibitory neurotransmitter involved in a variety of psychiatric and neurological disorders. Due to the intense creatine methyl signal at 3.0 ppm, small movements of the subject and carrier frequency drift can lead to severe subtraction errors using the conventional two-step subtraction editing methods. Accurate and objective phase correction requires a phase marker with high SNR and an automatic routine with minimal user intervention. Here we report a robust phase correction routine using residual water as the internal navigator signal, which significantly minimized subtraction errors in GABA editing.