CASL Perfusion fMRI Revealed Altered Resting Brain Function in Prenatally Cocaine Exposed Teenagers
Rao H, Wang J, Hurt H, Gee J, Detre J, Avants B, Korczykowski M, Giannetta J, Shera D
University of Pennsylvania
The present study used CASL perfusion fMRI and optimized VBM to explore the effect of prenatal cocaine exposure (PCE) on the neurocognitive development of adolescents' brain. Compared to socioeconomically matched controls, perfusion fMRI observed globally reduced CBF particularly in the posterior brain, while regional CBF was relatively increased in anterior brain areas involved in emotional and arousal processing in cocaine-exposed teenagers. Optimized VBM revealed that PCE may increase the gray matter volume in the insula-amygdala areas. These results supported that PCE affects emotional processing and suggested that PCE may alter the spatial distribution of resting brain function in adolescents.