Pre-surgery Lactate, Lipid, and ADC Predict Survival for Patients with Glioblastoma Multiforme
Oh J, Park I, Cha S, Khayal I, Lamborn K, Choy R, Saraswathy S, Chang S, Nelson S, Crawford F
University of California
Accurate prediction of survival for newly diagnosed Glioblastoma Multiforme (GBM) patients could assist oncologists in evaluation of the effectiveness of new therapies in clinical trials by providing an improved baseline estimate of survival. We studied 54 patients with GBM who had undergone no prior resection or treatment to determine whether MR spectroscopic imaging or diffusion-weighted MRI markers would predict survival immediately prior to surgery. The results of our study suggest that the average normalized values of lactate and lipid measured within the T2 hyperintense region, and ADC measured within the contrast-enhancing and necrotic regions may be predictive of survival.