In-Vivo Cardiac IRON Imaging of MR Fluoroscopically Delivered Mesenchymal Stem Cells
Stuber M, Gilson W, Bulte J, Shah S, Kraitchman D, Kedziorek D
Johns Hopkins University
The use of superparamagnetic particles has shown great promise for cardiac stem cell research. However, competing sources of negative contrast and constant intrinsic and extrinsic myocardial motion adversely affect the interrogation of iron-labeled stem cells that are injected into the myocardium. For these reasons, we have developed a motion-suppressed 1.5T and 3T imaging sequence that enables hyperintense in-vivo visualization of iron labeled stem cells.