Quantification of Myocardial Lipid using a Breath Hold Multiecho Technique at 3.0 Tesla
O'Regan D, Schmitz S, Callaghan M, Naoumova R, Fitzpatrick J, Allsop J, Hajnal J
Hammersmith Hospital, Imperial College
The accumulation of lipid within the myocardium is associated with impairment of both systolic and diastolic function in animal models. A black blood cardiac-triggered gradient echo sequence was designed to acquire five echoes during a single breath-hold on a 3.0 tesla MRI system. The echo times were chosen such that fat and water resonances were either in-phase or out-of-phase with respect to each other. Images were acquired of lipid emulsion phantoms and in both volunteers and patients. A curve fitting model was used to derive the relative fat and water content of myocardium.