Hepatocellular adenoma and the surrounding liver: a spectrum of characteristic findings at state-of-the-art MR imaging, with histopathological correlation
van den Bos I, Hussain S, Wielopolski P, de Man R, IJzermans J, Zondervan P
Erasmus Medical Center
Hepatocellular adenoma (HA) has an increased risk of hemorrhage and malignant transformation in large (>5 cm) lesions. Differentiation with focal nodular hyperplasia (FNH) is important, since HA are sensitive to hormonal levels and may grow during use of oral anticonception, or pregnancy, with risk of potentially life-threatening bleeding. To evaluate image characteristics of liver and lesions, a retrospective analysis was performed with histopathological correlation. It is shown that liver parenchyma in case of HA has often changed in morphology, signal intensity and histopathology. Also, most lesions show either partial or marked fatty infiltration, which may facilitate differentiation with FNH.