RADIOLOGIST SELECTION OF TUMOR REGIONS OF INTEREST FOR DYNAMIC CONTRAST ENHANCED MRI ANALYSIS: EFFECT ON REPRODUCIBILITY AND SPREAD OF MODELLED AND NON-MODELLED PARAMETERS
Tang A, deSouza N, Collins D, Wallace T, d'Arcy J, Leach M, Walker-Samuel S
Institute of Cancer Research
Radiologist selection can isolate regions within a tumor, which have significantly higher modelled and non-modelled measures of perfusion and permeability with significantly lower variation. However, ROI selection does not improve reproducibility of either modelled or non-modelled DCE-MRI parameters, suggesting that tumor heterogeneity is not the major factor contributing to reproducibility.