What is the optimal cohort size for a reproducibility study of dynamic contrast-enhanced MRI?
Taylor N, Stirling J, Padhani A, Leach M, d'Arcy J, Collins D, Rustin G, Koh D, Tang A, Knowles B, Lee C, Wallace T
Mount Vernon Hospital
The measurement of test-retest variability is an integral part of study design of dynamic MRI (DCE-MRI) studies that evaluate the effectiveness of antiangiogenesis and angiolytic drug trials. In this study we investigate the effect of increasing numbers of patients on the reproducibility of DCE-MRI studies in order to define the number of patients needed to adequately define test-retest variability.