Voxel Based Morphometry and Manual Volumetric Analysis of the Cingulate Gyrus in Patients with Juvenile Myoclonic Epilepsy and Frontal Lobe Epilepsy Compared to Normal Controls
Nalcioglu O, Su M, Vu L, Mandelkern M, Head K, Swartz B
University of California, Irvine
Voxel Based Morphometry (VBM) and Manual Volumetric Analysis (MVA) were performed to analyze the difference in brain morphology between 19 patients with epilepsy (10 JME, 9 FLE), and 9 controls. VBM analysis reveals that FLE subjects had less cingulate volume than the controls and the JME, confirmed by the results obtained by MVA. Both FLE and JME had atrophy in middle temporal gyrus, insula and parahippocampal gyrus. Atrophy in parahippocampal gyrus may be related to memory deficit in epilepsy patients. The results also suggest that it may be possible to differentiate FLE and JME based on the cingulate atrophy.