A Correlational Analysis of Cognitive fMRI, DTI, and Clinical Assessment of Multiple Sclerosis
Goodyear B, Lau R
University of Calgary
To date, MR imaging studies of Multiple Sclerosis have not investigated the inter-relationship of cognitive fMRI and white matter integrity as measured by DTI, as well as their correlation with current clinical assessments. Understanding these inter-relationships may provide a more complete description of the progression of MS, and could lead to an imaging protocol that, in combination with behavioral assessment, is a comprehensive and accurate clinical evaluation. The objective of this study was to identify correlations between existing clinical measures of MS severity with brain activity measured using fMRI and with ROI-based measurements of fractional anisotropy.