Assessments of diffusion sensitivity in identifying brain lesions in clinically isolated syndrome subjects
Jewells V, Lin W, An H, Bullitt E, Chen Y
The Univ. of North Carolina at Chapel Hill
The main thrust of this study was to determine the sensitivity of diffusion weighted imaging in delineating MS lesions in clinically isolated syndrome (CIS) subjects, a cohort of subjects who experience one exacerbation consistent with MS but have not been clinically diagnosed as MS patients. Clinically used T2-weigted images were used as the gold standard to define the ground truth of MS lesions.