Combined MRI/MRS Protocol for Specificity Improvement in Breast Cancer Detection
Huang W, Tudorica L, Fisher P, Dulaimy K, Button T, O'Hea B
Memorial Sloan-Kettering Cancer Center
The goal of this study was to determine if a combined MRI/MRS protocol of dynamic contrast enhanced (DCE) T1-weighted MRI, 1H MRS, and perfusion MRI improves specificity in detection of breast malignancy. 87 patients with positive mammography findings were studied. After DCE MRI showed fast contrast enhancement, single-voxel 1H MRS and perfusion MRI examinations were performed. DCE MRI showed 100% sensitivity and 56% specificity in detection of breast cancer. The specificity improved to 85% with the addition of 1H MRS, and to 100% with the further addition of perfusion MRI.