Kyle Stephan McCommis1, Xiang He1, Dana R. Abendschein2, Pradeep M. Gupte3, Robert J. Gropler1, Jie Zheng1
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; 2Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA; 3Rockland Technimed Ltd, Airmont, NY, USA
A new MRI method is presented to calculate the myocardial oxygen consumption rate (MVO2) using 17O-enriched blood. Initial in vivo study was performed in normal dogs, as well as in one dog with a severe coronary stenosis. A cardiac T1ρ -weighted imaging sequence was developed to monitor myocardial T1ρ signals with and without the presence of metabolic H217O water. Various doses of 17O-blood were injected intravenously, followed by the injection of 16O-blood. MVO2 can then be quantified using a simplified model.