Kieren Grant Hollingsworth1, David EJ Jones2, Jessie Pairman2, Katherine Wilton2, Roy Taylor1, Julia Lindsay Newton2, Andrew Mark Blamire1
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, Tyne and Wear, UK; 2Institute of Cellular Medicine, Newcastle University, Newcastle, Tyne and Wear, UK
Primary Biliary Cirrhosis is an autoimmune liver disease affecting females from middle age. A follow-up study of 770 PBC patients studies indicated an increased risk of cardiac-related death. Phosphorus MRS and anatomical imaging for cardiac morphology were acquired to look for cardiac metabolic stress and dysfunction. For 15 PBC patients, the PCr/ATP ratio was significantly reduced compared to age and weight-matched control subjects, but there was no difference in left ventricle morphology, suggesting metabolic stress only. There was no correlation between PCr/ATP ratio, fatigue severity or age, suggesting that cardiac metabolic stress is a systemic feature of the disease.