Kun-Hsien Chou1, Hsuan-Hui Wang2, Wan-You Guo3, Ming-Tak Ho4, Ming-Hsiung Chen5, Woei-Chyn Chu1, Ching-Po Lin2,6
1Institute of Biomedical Engineering,
National Yang Ming University, Taipei, Taiwan; 2Institute of Biomedical
imaging and Radiological Sciences, National Yang Ming University, Taipei,
Taiwan; 3Division of Neuroradiology, Taipei Veterans General
Hospital, Taipei, Taiwan; 4Department of Pathology, Taipei Veterans
General Hospital, Taipei, Taiwan; 5Institute of Neurological
Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan; 6Institute
of Neuroscience, National Yang Ming University, Taipei, Taiwan
Peritumoral signal abnormalities (PSA) of brain tumors contain varieties of tissues, and are categorized mainly to abnormal protons (vasogenic edema, gliosis) and/or tumor infiltration. In clinical experience, T2-weighted MR images are usually used to identify PSA in patients with tumors, even though the two types of signal abnormalities can still hardly be distinguished effectively up to date. In an attempt to circumvent this problem, a novel method was proposed and DTI was applied to differentiate the complex contents of PSA by reversibility. Differentiating tissue contents of PSA may facilitate tumoral delineation and therefore change the therapeutic strategy.