Ulrike Lbel1, Jan Sedlacik1, Mehmet Kocak2, Alberto Broniscer3, Claudia M. Hillenbrand1, Zoltn Patay1
1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA; 3Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA
Two-dimensional gradient-echo imaging and susceptibility-weighted imaging (SWI) enhance visualization of magnetically susceptible substances such as hemorrhage and calcification. In patients with diffuse pontine glioma treated with conformal radiation and vandetanib, an angiogenesis inhibitor, both techniques were compared regarding their accuracy and validity for detecting hemorrhagic lesions. Image analysis and interpretation were found to be more accurate and straightforward with SWI as fewer lesions were missed or misinterpreted. We found that both techniques benefited from the availability of phase images, especially for differentiation of hemorrhage from calcification. However, SWI will likely become the new gold standard for imaging magnetically susceptible substances.