Ralf Berthold Loeffler1, Song Wu2, Nicole van Groningen1, Zoltan Patay1, John O. Glass1, Matthew P. Smeltzer2, Claudia Maria Hillenbrand1
1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA
Quantitative IR-TrueFISP T1 and T2 maps are sensitive to variation in the RF excitation pulse. To overcome this problem we developed a model for the transformation of IR-TrueFISP derived relaxation parameters in a large patient data set toward gold standard reference signals by density-varying calibration functions fitted through a natural cubic spline. We were able to create a calibration function that transforms the IR-TrueFISP such that the fitting error between the conventional data and the IR-TrueFISP data became very small and showed almost no bias, especially for the T2 values, which are usually more error prone.