Surya C. Gnyawali1, Molly McCoy2, Sashwati Roy2, Chandan K. Sen2
1Heart and Lung Research Institute, The Ohio State University, Columbus , OH, USA; 2Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
p21 protein available in the myocardium worsens the heart function after ischemia and reperfusion (I-R). All of the cardiac functional parameters show significantly better outcomes in p21-knockout mice compared to its wild type. Which concludes that p21-dependent pathways contribute to post I-R myocardial fibrosis.