Abstract #1792

Cardiac Cine MRI Reveals Ischemia-Reperfused Heart Suffers a Compromise in Its Function: P21 as an Oxygen-Sensitive Regulator of Fibrosis

Surya C. Gnyawali¹, Molly McCoy², Sashwati Roy², Chandan K. Sen²

¹Heart and Lung Research Institute, The Ohio State University, Columbus , OH, USA; ²Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

p21 protein available in the myocardium worsens the heart function after ischemia and reperfusion (I-R). All of the cardiac functional parameters show significantly better outcomes in p21-knockout mice compared to its wild type. Which concludes that p21-dependent pathways contribute to post I-R myocardial fibrosis.