Hlne Ratiney1, Yann Le Fur2, Michal Sdika2, Sophie Cavassila3
1Universit de Lyon, CREATIS-LRMN; CNRS UMR 5220; Inserm U630; INSA-Lyon; Universit Lyon 1, Villeurbanne, France; 2Universit Aix-Marseille II, CRMBM, CNRS UMR 6612, Marseille, France; 3Universit de Lyon,, CREATIS-LRMN; CNRS UMR 5220; Inserm U630; INSA-Lyon; Universit Lyon 1, Villeurbanne, France
Short echo time chemical shift imaging (SE-CSI) data quantification at 11.7T in the mouse brain is challenging because the magnetic field inhomogeneity impact the quality of both water suppression and spectral resolution and macromolecular contamination can vary from voxel to voxel. We propose to derive from macromolecular CSI acquisition a constrained parametric macromolecular model to incorporate strong prior knowledge into the fitting of the SE-CSI. Evaluation of this approach on in vivo data acquisition is proposed and discussed.