Jamie Near1, Philip J. Cowen1, Peter Jezzard2
1Department of Psychiatry, University of Oxford, Oxford, OXON, United Kingdom; 2The Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Oxford, OXON, United Kingdom
GABA editing using the MEGA-PRESS technique at 3T results in signal contamination from macromolecules. We present a modified spectral editing technique called MEGA-SPECIAL, which enables the use of longer, more frequency-selective editing pulses. This, in turn, enables the use of previously described strategies for the removal of macromolecular contamination. In-vitro measurements indicate that the newly developed sequence provides improved editing efficiency over MEGA-PRESS, and experiments performed in-vivo confirm that macromolecular suppression is achieved.