Ya Chen1,2, Wen Li1,2, Wei Li1,2, Xin Yu1,2
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States
The present study aimed to quantify manganese (Mn2+) uptake in hearts under altered physiological and biochemical conditions. Using a rapid T1-mapping method, we investigated the dynamic Mn2+ uptake in perfused rat hearts 1) under normal workload; 2) under isoproterenol (ISO) stimulation, and 3) at elevated calcium (Ca2+) concentration. Our results show that Mn2+ uptake was increased in ISO stimulated hearts but not in hearts perfused with increased Ca2+ concentration.