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Abstract #0488

Diffusion Weighted MRI of the Mouse Heart in Vivo Following Ischemia-Reperfusion Injury

Shuning Huang1, Guangping Dai1, David E. Sosnovik1,2

1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, United States


We present in the study, to the best of our knowledge, the first diffusion weighted MR images of the mouse heart to be acquired in vivo. Schemes to overcome motion artifact in the rapidly beating mouse heart are presented, and the ability of the technique to detect changes in cell death in the myocardium after an ischemic insult is demonstrated.