Sebastian
Hirsch1, Kaspar Josche Streitberger1, Jan Rodrigo
Hoffmann2, Randolf Klingebiel3, Dieter Klatt1,
Sebastian Papazoglou1, Jrgen Braun4, Ingolf Sack1
1Institute of Radiology, Charit -
University Medicine Berlin, Berlin, Germany; 2Institute of
Neurology, Charit - University Medicine Berlin, Berlin, Germany; 3Institute
of Neuroradiology, Charit - University Medicine Berlin, Berlin, Germany; 4Institute
of Medical Informatics, Charit - University Medicine Berlin, Berlin, Germany
The
characterization of neuronal tissue inside an infarcted region is still a
subject of intense research. MR elastography (MRE) is capable of measuring
the mechanical connectivity of soft tissue in vivo. This feasibility study
aims to assess the potential of MRE for the characterization of tissue
regeneration after stroke. The hypothesis was that stroke-related changes of
the biomechanical properties of neuronal tissue are detectable by MRE. The
results demonstrate through both a decrease in the complex shear modulus and
an increase in shear wave amplitudes that tissue integrity is degraded inside
a stroke region.