Judong Pan1, Christoph Stehling2,3, Christina Muller-Hocker4, Benedikt Jakob Schwaiger5, John Lynch6, Michael Nevitt6
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA , United States; 2Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 3Department of Clinical Radiology, University of Muenster, Germany; 4Technical University of Munich, Germany; 5Ludwig-Maximilians University of Munich, Germany; 6Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States
Quadriceps strength has been extensively studied in relationship to knee osteoarthritis (OA). However, the role of vastus lateralis and vastus medialis in OA remains unclear. We examined 176 non-symptomatic subjects with risk factors for OA selected from the Osteoarthritis Initiative incidence cohort using cartilage T2 mapping technique and 3 Tesla MRI morphological analyses. We found that higher vastus lateralis to medialis cross-sectional area ratio is associated with significantly lower cartilage T2 values and less morphological abnormalities detected by MRI. Our data suggested that vastus lateralis/medialis balance may play an important role in the pathogenesis of early OA.