Laura Mancini1,2, Rathie Rajendram3, Jimmy Uddin3, Richard W J Lee4, Geoffrey E. Rose3, Tarek Yousry1,2, Katherine Miszkiel1,3, John S. Thornton1,2
1Lysholm Dept Neuro-radiology, National Hospital for Neurology and Neurosurgery, Univ College London Hospitals NHS Foundation Trust, London, United Kingdom; 2Academic Neuroradiological Unit, Institute of Neurology, University College of London, London, United Kingdom; 3Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 4Academic Unit of Ophthalmology, Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom
This study shows that there is correlation between T2 relaxation values in the extra-orbital muscles of patients with thyroid eye disease and Clinical Activity Score (CAS). CAS is the gold-standard measure of disease activity, considered to reflect the degree of orbital inflammation, while T2-weighted images are sensitive to changes in tissue water content concomitant with extra-orbital muscle inflammation. This study represents a validation of T2 measurements as outcome measures for studies of interventions in TED. T2 measures have therefore the potential to improve the quality of data reported in Randomised Control Trials.