Alan Bainbridge1, Giles Kendall2,
Enrico DeVita3, Cornelia Hagmann2, Andrew Kapetanakis2,
Ernest Cady1, Nicola Robertson2
1Medical Physics and Bioengineering,
UCL Hospitals NHS Foundation Trust, London, United Kingdom; 2Academic
Neonatology, EGA UCL Institute for Womens Health, University College London,
London, United Kingdom; 3UCL Hospitals NHS Foundation Trust,
Medical Physics and Bioengineering, London, United Kingdom
Therapeutic
cerebral hypothermia is an effective and safe treatment for perinatal
asphyxial encephalopathy. Precise knowledge of regional brain temperature is
needed in order to optimise therapeutic hypothermia. Proton MRS can be used
to estimates regional brain temperature. Reliable absolute temperature
measurement depends on good calibration data and robust clinical spectrum
acquisition. Serial acquisition of
subspectra allows both removal of motion-corrupted data and frequency
correction of the remaining subspectra to remove effects of static magnetic
field decay. The magnetic field decay
correction significantly reduced fitted peak linewidths and increased the
precision of the measurement.