Jacob Penner1,2, Andrew Curtis1,2,
Martyn Klassen1, Joseph Gati1, Matthew Smith3,
Michael J. Borrie3,4, Robert Bartha1,2
1Centre for Functional and Metabolic
Mapping, Robarts Research Institute, London, ON, Canada; 2Medical
Biophysics, University of Western Ontario, London, ON, Canada; 3Division
of Aging, Rehabilitation, and Geriatric Care, Lawson Health Research
Institute, London, ON, Canada; 4Department of Medicine, University
of Western Ontario, London, ON, Canada
The
purpose of this study was to determine the optimal inversion time to null
metabolite signals allowing accurate measurement of the macromolecule
baseline for quantitative 1H MR spectroscopy at 7T. Spectra were acquired within a phantom
using single-voxel localization by adiabatic selective refocusing
(LASER). The TI values that would
result in complete suppression of NAA and Cr were found to be 0.47 seconds
and 1.27 seconds, respectively.
Furthermore, T1 values were found to be 1.28 seconds for NAA and 2.45
seconds for Cr. Future work will
extend this method to determine the optimal TI values for in-vivo metabolite
suppression.