Stefan Haneder1, Simon Konstandin2, Frank G. Zllner2, Armin M. Nagel3, Lothar R. Schad2, Stefan O. Schnberg1, Henrik J. Michaely1
1University Medical Center Mannheim, Institute of Clinical Radiology and Nuclear Medicine, Mannheim, Baden-Wrttemberg, Germany; 2Heidelberg University, Computer Assisted Clinical Medicine, Mannheim, Baden-Wrttemberg, Germany; 3German Cancer Research Center, Department of Medical Physics in Radiology, Heidelberg, Baden-Wrttemberg, Germany
Sodium imaging before/after water load (1L) was performed with 9 healthy volunteers. A density adapted 3D radial trajectory gradient-echo sequence was used at a 3T clinical MR scanner. Linear cortico-medullary sodium gradients were assessed before/after water load. Using standardized sodium phantoms these gradients were quantified. A decrease of the quantitative sodium concentration of about 22% after water load was stated. This study suggests that sodium imaging might be an appropriate, noninvasive method for physiological imaging of the human kidney. The current technique is sufficient for the quantification of the renal sodium concentration and its change in different physiological conditions.