Haoyang Xing1,2, Hao Shen3, Hehan
Tang1, Xiaoqi Huang1, Qiyong Gong1, Xiaohong
Joe Zhou2,4
1Center for MR Research, West China
Hospital, Sichuan University, Chengdu, Sichuan, China; 2Center for
MR Research, University of Illinois Medical Center, Chicago, IL, United
States; 3GE Healthcare, Beijing, China; 4Departments of
Radiology, Neurosurgery, and Bioengineering, Chicago, IL, United States
Characterization
of phosphocreatine (or PCr) in biological tissues can provide valuable
information on tissue physiology and metabolism and may lead to sensitive
disease markers. We have developed 2D
and 3D spectrally selective PCr imaging techniques on a human 3T MRI
scanner. Low resolution PCr images
(32x32) can be obtained in 10.8 minutes with an SNR of ~4, boding well for
further developing these techniques for human applications.