Lasitha Senadheera1, Dirk Mayer2,3,
Moses Darpolor2, Yi-Fen Yen4, Lei Xing1,
Daniel Spielman2
1Radiation Oncology, Stanford
University, Stanford, CA, United States; 2Radiology, Stanford
University, Stanford, CA, United States; 3Neuroscience Program,
SRI International, Menlo Park, CA, United States; 4Global Applied
Science Laboratory, GE Healthcare, Menlo Park, CA, United States
Radiation
dose to the tumors is often limited by the irradiation of adjacent organs at
risk, such as kidneys. Unlike structural change, metabolic response may
reflect early signs of radiation damage in tissues, offering opportunity to
better design radiotherapy. Following hyperpolarized [1-13C]pyruvate
injection, 13C MRSI was employed to detect radiation-induced metabolic
response in rat kidneys at various radiation doses and postirradiation times.
No trend in Lactate/pyruvate ratios was observed between irradiated and
normal kidneys of the same animal. Metabolic response of irradiated kidneys
might not be strong enough to become visible in 13C MRSI, within our
experimental errors and conditions.