Hermien E. Kan1, Matthias J.P. van Osch1, Maarten J. Versluis1, Aranee Techawiboonwong2, Dinesh K. Deelchand3, Pierre G. Henry3, M Marjanska3, Mark A. van Buchem1, Andrew G. Webb1, Itamar Ronen, 12
1C.J. Gorter Center, department of radiology, Leiden University Medical Center, Leiden, Netherlands; 2Radiology, Boston University, Boston, United States; 3Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States
Assessment of diffusive properties of metabolites using diffusion weighted spectroscopy has so far been, in humans, limited to the brain metabolites N-acetyl aspartate, creatine and phosphocreatine and choline. To further assess substructural differences, it would be advantageous to also study ADCs of other metabolites, like myo-inositol, glutamate and glutamine. In this study, we obtained ADC values of these metabolites in human grey and white matter, and observed that in grey matter overall ADCs were lower compared to white matter with a significantly reduced glutamate. This is in agreement with observations in monkeys, and indicates increased diffusion restriction in grey matter.