Emily Turner Wood1,2, Daniel S. Reich2,3, Jonathan A. Farrell3,4, Joseph S. Gillen4, Peter B. Barker3, Itamar Ronen5
1Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2NeuroImmunology Branch (NINDS), National Institutes of Health, Bethesda, MD, United States; 3Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 5Leiden University Medical Center, Leiden, Netherlands
Diffusion tensor spectroscopy (DTS) combines features of DTI and spectroscopy to provide information about the diffusion of intracellular metabolites and therefore specific information about tissue microstructure and health. We compare the diffusion properties of N-acetylaspartate (NAA) and water at two locations in the corpus callosum at 7T. Subjects were scanned at 7T with a 32-channel head coil using a DTS sequence that incorporated bipolar diffusion gradients within a point-resolved spectroscopic (PRESS) sequence. We demonstrate high resolution spectra and diffusion values consistent with previous reports at lower fields, demonstrating the feasibility of DTS at 7T to quantify a range of metabolites.