Nathan S. Artz1, Andrew L. Wentland1, Elizabeth A. Sadowski2, Thomas M. Grist, 12, Arjang Djamali3, Sean B. Fain1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Nephrology, University of Wisconsin-Madison, Madison, WI, United States
Two methods of measuring cortical kidney perfusion, fluorescent microspheres and ASL-FAIR, are compared for 11 swine each at four interventional time points: 1) under baseline conditions, 2) during an acetylcholine and fluid bolus challenge to increase perfusion, 3) initially after switching to isoflurane anesthesia , and 4) after two hours of isoflurane anesthesia. Across all swine, microspheres and ASL correlated (r = 0.72) and each technique tracked the expected perfusion changes due to the interventions, demonstrating statistical differences in perfusion (p < 0.05) between time points. In addition, ASL perfusion data was more consistent across swine. This data provides validation of ASL-FAIR for relative renal perfusion imaging, especially for evaluating time-averaged perfusion changes that may be observed in chronic disease.