Joseph Mettenburg1, David N. Daniels1, Yvette I. Sheline, 12, Beau Ances3, Huiling Peng3, Abraham Z. Snyder1, John C. Morris3, Mark A. Mintun1, Tammie L.S. Benzinger4
1Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2Psychiatry, Washington University in Saint Louis; 3Neurology, Washington University in Saint Louis; 4Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St. Louis, MO, United States
Amyloid plaque deposition in the brain is one of the key pathological hallmarks of Alzheimers disease. Recently, CSF amyloid beta42 peptide levels and PET scans using C-11 Pittsburgh Compound B (PIB) have been established as potential biomarkers for dementia of the Alzheimers type (DAT). Using DTI, we evaluated white matter microstructure in subjects with and without established DAT and identified differences in both the corpus callosum and precuneus. The same white matter findings were identified in non-demented subjects with positive CSF and PIB-PET, suggesting that microstructural abnormalities in white matter integrity may precede cognitive changes in DAT.