Abstract #2002

Investigation of Cerebral Ischemic Disease in the Aged with Aortic Stenosis

Ping Wang¹, Elizabeth Strambrook², Michel Bilello¹, Thomas Floyd³

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Anesthesiology & Critical Care, University of Pennsylvania, Philadelphia, PA, United States; ³Anesthesiology & Critical Care, and Neurology, University of Pennsylvania, Philadelphia, PA, United States

To test the correlations of aging, sex, and aortic stenosis (AS) degree with the severity of pre-existing white matter and ischemia-like lesions. Aging was associated with rapidly progressive cerebral ischemic disease; female sex accounted for a 56% increased in lesion volume over men; while the severity of AS did not demonstrate statistical significance in influencing lesion volume, univariate analysis demonstrated an important trend of increasing lesion volume with increasing severity of AS.