Ai Wern Chung1, Rebecca A. Charlton1, Nigel C. Lawes2, Robin G. Morris3, Hugh S. Markus1, Thomas R. Barrick1
1Centre for Clinical Neuroscience, Saint George's University of London, London, United Kingdom; 2Graduate Medical School, University of Limerick, Limerick, Ireland; 3Department of Psychology, Institute of Psychiatry, King's College University of London, London, United Kingdom
We present a novel technique applying probabilistic diffusion tensor tractography on longitudinal data to assess white matter structural integrity in ageing subjects over a period of two years. Our method was able to consistently extract white matter tracts associated with working memory over time and between two ageing cohorts (middle-aged and elderly). Tract connections were found between the fronto-temporal, fronto-parietal and temporo-parietal lobes. Our study suggests a decrease in white matter structural integrity of these tracts with age could be related to the decline in working memory performance.