Vitria Adisetiyo1, Sarah S. Milla2, Howard Weiner3, Caixia Hu2, Ali Tabesh2, Jens H. Jensen1,2, Joseph A. Helpern1,2
1Neuroscience and Physiology, New York University School of Medicine, New York, NY, United States; 2Radiology, New York University School of Medicine, New York, NY, United States; 3Neurosurgery, New York University School of Medicine, New York, NY, United States
Tuberous Sclerosis Complex (TSC) is a rare genetic disease that manifests in the CNS as cortical/subcortical tuber lesions consisting of abnormal dysplastic neurons. Tubers are presumed to contribute to epileptogenesis and to developmental delays in TSC. Given several reports of silent tubers with active surrounding perilesion tissue, we applied Diffusional Kurtosis Imaging (DKI) to quantitatively characterize the microstructure of tubers as compared to surrounding perilesion and normal appearing contralateral tissue in TSC patients aged 2-10 years and age-matched controls. Region of interest analysis found that only tubers are associated with significant increase in diffusivity and substantial decrease in microstructural heterogeneity.